An lrp-like gene of Bacillus subtilis involved in branched-chain amino acid transport

Summary, in English

The azlB locus of Bacillus subtilis was defined previously by a mutation conferring resistance to a leucine analog, 4-azaleucine (J. B. Ward, Jr., and S. A. Zahler, J. Bacteriol. 116:727-735, 1973). In this report, azlB is shown to be the first gene of an operon apparently involved in branched-chain amino acid transport. The product of the azlB gene is an Lrp-like protein that negatively regulates expression of the azlBCDEF operon. Resistance to 4-azaleucine in azlB mutants is due to overproduction of AzlC and AzlD, two novel hydrophobic proteins.

• Författare: B R Belitsky; Mattias Gustafsson; A L Sonenshein; Claes von Wachenfeldt
• Avdelning/ar: Institutionen för laboratoriemedicin; Molekylär cellbiologi; Mikrobiologigruppen
• Publiceringsår: 1997
• Språk: Engelska
• Sidor: 5448-5457
• Publikation/Tidskrift/Serie: Journal of Bacteriology
• Volym: 179
• Issue: 17
• Länkar: http://www.pubmedcentral.nih.gov/articlerender.fcgi?rendertype=abstract&artid=179416
• Dokumenttyp: Artikel i tidskrift
• Förlag: American Society for Microbiology
• Ämne: Microbiology
• Status: Published
• Forskningsgrupp: Microbiology Group
• ISBN/ISSN/Övrigt: ISSN: 0021-9193