Radiolabeled antibodies in prostate cancer: A case study showing the effect of host immunity on antibody bio-distribution.
Författare
Summary, in English
Human tumors xenografted in immunodeficient mice are crucial models in nuclear medicine to evaluate the effectiveness of candidate diagnostic and therapeutic compounds. However, little attention has been focused on the biological profile of the host model and its potential effects on the bio-distribution and tumor targeting of the tracer compound under study. We specifically investigated the dissimilarity in bio-distribution of (111)In-DTPA-5A10, which targets free prostate specific antigen (fPSA), in two animal models.
Avdelning/ar
- Medicinsk strålningsfysik, Lund
- Urologisk cancerforskning, Malmö
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Klinisk kemi, Malmö
- Lund University Bioimaging Center
- EpiHealth: Epidemiology for Health
Publiceringsår
2015
Språk
Engelska
Sidor
375-380
Publikation/Tidskrift/Serie
Nuclear Medicine and Biology
Volym
42
Issue
4
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Radiology, Nuclear Medicine and Medical Imaging
Status
Published
Forskningsgrupp
- Urological cancer, Malmö
- Clinical Chemistry, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1872-9614