Webbläsaren som du använder stöds inte av denna webbplats. Alla versioner av Internet Explorer stöds inte längre, av oss eller Microsoft (läs mer här: * https://www.microsoft.com/en-us/microsoft-365/windows/end-of-ie-support).

Var god och använd en modern webbläsare för att ta del av denna webbplats, som t.ex. nyaste versioner av Edge, Chrome, Firefox eller Safari osv.

Antileishmanial metabolites from Trixis antimenorrhoea

In English

Författare

  • Eliana Maldonado
  • Efrain Salamanca
  • Alberto Gimenez
  • Gloria Saavedra
  • Olov Sterner

Summary, in English

An ethanol extract of the aerial parts of Trixis antimenorrhoea was found to possess activity toward Leishmania brasiliensis. Two new metabolites, the nortrixane 1 and the trixanolide 2, and eleven known were isolated and characterized. The antileishmanial activity against the promastigote form of L. amazonensis and L. brasiliensis was assayed in vitro, and 2 exhibited potent activity with IC50 values below 1 mu g/mL toward both strains. The structures of the isolated compounds were elucidated by NMR spectroscopy and high-resolution mass spectrometry, and the absolute configuration of 2 was determined by using Mosher's ester protocol. (C) 2014 Phytochemical Society of Europe. Published by Elsevier B.V. All rights reserved.

Publiceringsår

2014

Språk

Engelska

Sidor

281-286

Publikation/Tidskrift/Serie

Phytochemistry Letters

Volym

10

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Chemical Sciences

Nyckelord

  • Trixis antimenorrhoea
  • Nortrixane
  • Trixanolide
  • Antileishmanial
  • activity
  • Structural elucidation

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1874-3900