Furanocoumarins with affinity to brain benzodiazepine receptors in vitro

Summary, in English

Eight furanocoumarins were isolated from a methanol extract of dried roots of Angelica dahurica. One of these, phellopterin, strongly (IC50 = 0.36 microM) inhibits the binding of [3H]diazepam to central nervous system benzodiazepine receptors in vitro, while the others, despite their structural similarities with phellopterin, are considerably less active.

• Författare: Ola Bergendorff; Kim Dekermendjian; Mogens Nielsen; Rudong Shan; Robin Witt; Jinglu Ai; Olov Sterner
• Avdelning/ar: Dermatologi och venereologi, Lund; Centrum för analys och syntes
• Publiceringsår: 1997
• Språk: Engelska
• Sidor: 1121-1124
• Publikation/Tidskrift/Serie: Phytochemistry
• Volym: 44
• Issue: 6
• Länkar: http://dx.doi.org/10.1016/S0031-9422(96)00703-0
• Dokumenttyp: Artikel i tidskrift
• Förlag: Elsevier
• Ämne: Dermatology and Venereal Diseases
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0031-9422