Keratin 19 expression correlates with poor prognosis in breast cancer
Författare
Summary, in English
Breast cancer expression profiling has been used for determining biomarkers. Using gene expression profiles of 2,400 patients we identified keratin 19 (KRT19) as a highly deregulated gene in breast cancer. KRT19 expression is independent of patient race but correlates with disease grade, and ER, PR or HER2 expression. Expression of TPD52, GATA3 and KRT18 was increased in KRT19 expressing patients. Furthermore, KRT19 expression was associated with ER up-regulation and Luminal B gene signatures, as well as a constitutive RAF1 signaling pathway. Finally, KRT19 expression correlated with poor overall survival. Taken together, our results suggest that KRT19 expression can be used as a prognostic marker.
Avdelning/ar
- Avdelningen för translationell cancerforskning
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
Publiceringsår
2014
Språk
Engelska
Sidor
7729-7735
Publikation/Tidskrift/Serie
Molecular Biology Reports
Volym
41
Issue
12
Fulltext
Dokumenttyp
Artikel i tidskrift
Förlag
Springer
Ämne
- Cancer and Oncology
Nyckelord
- Cytokeratin 19
- CK19
- KRT19
- Microarray
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0301-4851