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Impact of transposable elements on the evolution of mammalian gene regulation.

In English

Författare

  • Patrik Medstrand
  • L N van de Lagemaat
  • C A Dunn
  • J-R Landry
  • Daniel Svenback
  • D L Mager

Summary, in English

Transposable elements (TEs) are present in all organisms and nearly half of the human and mouse genome is derived from ancient transpositions. This fact alone suggests that TEs have played a major role in genome organization and evolution. Studies undertaken over the last two decades or so clearly show that TEs of various kinds have played an important role in organism evolution. Here we review the impact TEs have on the evolution Of gene regulation and gene function with an emphasis on humans. Understanding the mechanisms resulting in genomic change is central to our understanding of gene regulation, genetic disease and genome evolution. Full comprehension of these biological processes is not possible without an in depth knowledge of how TEs impact upon the genome.

Publiceringsår

2005

Språk

Engelska

Sidor

342-352

Publikation/Tidskrift/Serie

Cytogenetic and Genome Research

Volym

110

Issue

1-4

Dokumenttyp

Artikel i tidskrift

Förlag

Karger

Ämne

  • Basic Medicine
  • Pharmacology and Toxicology

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1424-859X