Systemic Monocytic-MDSCs Are Generated from Monocytes and Correlate with Disease Progression in Breast Cancer Patients.

Summary, in English

Myeloid-derived suppressor cells (MDSCs) are highly immunosuppressive myeloid cells, which increase in cancer patients. The molecular mechanism behind their generation and function is unclear. Whereas granulocytic-MDSCs correlate with poor overall survival in breast cancer, the presence and relevance of monocytic-MDSCs (Mo-MDSCs) is unknown. Here we report for the first time an enrichment of functional blood Mo-MDSCs in breast cancer patients before they acquire a typical Mo-MDSC surface phenotype. A clear population of Mo-MDSCs with the typical cell surface phenotype (CD14+HLA-DRlow/-CD86low/-CD80low/-CD163low/-) increased significantly first during disease progression and correlated to metastasis to lymph nodes and visceral organs. Furthermore, monocytes, comprising the Mo-MDSC population, from patients with metastatic breast cancer resemble the reprogrammed immunosuppressive monocytes in patients with severe infections, both by their surface and functional phenotype but also at their molecular gene expression profile. Our data suggest that monitoring the Mo-MDSC levels in breast cancer patients may represent a novel and simple biomarker for assessing disease progression.

• Författare: Caroline Bergenfelz; Anna-Maria Larsson; Kristoffer von Stedingk; Sofia Gruvberger; Kristina Aaltonen; Sara Jansson; Helena Jernström; Helena Janols; Marlene Wullt; Anders Bredberg; Lisa Rydén; Karin Leandersson
• Avdelning/ar: Bröstcancerkirurgi; The Liquid Biopsy och Tumörprogression i Bröstcancer; Cancerimmunologi, Malmö; Experimentell infektionsmedicin, Malmö; Bröstcancer-genetik; Avdelningen för translationell cancerforskning; Pediatrik, Lund; Tumörmikromiljö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Infectious Diseases Research Unit; Klinisk mikrobiologi, Malmö; Kirurgi, Lund
• Publiceringsår: 2015
• Språk: Engelska
• Publikation/Tidskrift/Serie: PLoS ONE
• Volym: 10
• Issue: 5
• Fulltext: - 2 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25992611?dopt=Abstract; http://dx.doi.org/10.1371/journal.pone.0127028
• Dokumenttyp: Artikel i tidskrift
• Förlag: Public Library of Science (PLoS)
• Ämne: Infectious Medicine; Cancer and Oncology
• Status: Published
• Projekt: CTC-MBC, Circulating Tumor Cells in Metastatic Breast Cancer; Breast Cancer Surgery
• Forskningsgrupp: Breast Cancer Surgery; The Liquid Biopsy and Tumor Progression in Breast Cancer; Cancer Immunology, Malmö; Experimental Infection Medicine, Malmö; Infectious Diseases Research Unit; Clinical Microbiology, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1932-6203