Statin-induced anti-proliferative effects via cyclin D1 and p27 in a window-of-opportunity breast cancer trial.

Summary, in English

Cholesterol lowering statins have been demonstrated to exert anti-tumoral effects on breast cancer by decreasing proliferation as measured by Ki67. The biological mechanisms behind the anti-proliferative effects remain elusive. The aim of this study was to investigate potential statin-induced effects on the central cell cycle regulators cyclin D1 and p27.

• Författare: Maria Feldt; Olöf Bjarnadottir; Siker Kimbung; Karin Jirström; Pär-Ola Bendahl; Srinivas Veerla; Dorthe Grabau; Ingrid Hedenfalk; Signe Borgquist
• Avdelning/ar: Bröstcancer - prevention & intervention; Bröstcancer-genetik; Tumörmikromiljö; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2015
• Språk: Engelska
• Publikation/Tidskrift/Serie: Journal of Translational Medicine
• Volym: 13
• Issue: 133
• Fulltext: - 2 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/25925673?dopt=Abstract; http://dx.doi.org/10.1186/s12967-015-0486-0
• Dokumenttyp: Artikel i tidskrift
• Förlag: BioMed Central (BMC)
• Ämne: Cancer and Oncology
• Status: Published
• Forskningsgrupp: Breast cancer prevention & intervention
• ISBN/ISSN/Övrigt: ISSN: 1479-5876