Evaluation of fluorescently labeled xylopyranosides as probes for proteoglycan biosynthesis
Författare
Summary, in English
A new fluorescent analog to the antiproliferative 2-(6-hydroxynaphthyl)-beta-D-xylopyranoside has been synthesized and tested on a T24 cell line. The new analog was efficiently uptaken by the T24 cells but did not initiate priming of GAG chains. The results are similar to other fluorescently labeled analogs and we propose that these compounds are too large and unpolar to efficiently function as GAG-primers. (c) 2007 Elsevier Ltd. All rights reserved.
Avdelning/ar
Publiceringsår
2007
Språk
Engelska
Sidor
2338-2341
Publikation/Tidskrift/Serie
Bioorganic & Medicinal Chemistry Letters
Volym
17
Issue
8
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Medicinal Chemistry
Nyckelord
- glycosaminoglycan
- fluorescent
- carbohydrates
- xylose
- proteoglycan
Status
Published
Forskningsgrupp
- Glycobiology
ISBN/ISSN/Övrigt
- ISSN: 0960-894X