Factor V Q506 (resistance to activated protein C) and prognosis after acute coronary syndrome
Författare
Summary, in English
Factor V:Q506 causing resistance to activated protein C (APC-resistance), is a risk factor for venous thrombosis. Some studies have indicated an association with arterial disease, especially in women. We investigated the prevalence of the FV:Q506 allele prospectively in 295 patients with acute coronary syndrome. Mortality and myocardial infarction rate were evaluated after 30 days and after 2 years. The FV:Q506 allele was found in 38 patients. In a Cox proportional hazards model, smokers carrying FV:Q506 had a higher risk of infarction or death within 30 days, compared to non-smokers with a normal genotype (relative risk 2.9 [95% CI 1.2-7.0]). The difference remained significant after 2 years (relative risk 2.8 [95% CI 1.2-6.5]). The effect of the FV:Q506 allele on clinical outcome in acute coronary syndrome has not previously been described. Our results demonstrate a gene-environment interaction between smoking and the FV:Q506 allele, with an increased risk of early complications after an acute ischemic event.
Avdelning/ar
Publiceringsår
1999
Språk
Engelska
Sidor
857-860
Publikation/Tidskrift/Serie
Thrombosis and Haemostasis
Volym
81
Issue
6
Dokumenttyp
Artikel i tidskrift
Förlag
Schattauer GmbH
Ämne
- Cardiac and Cardiovascular Systems
Nyckelord
- Activated Protein C Resistance
- Acute Disease
- Aged
- Alleles
- Coronary Disease
- Factor V
- Female
- Humans
- Male
- Middle Aged
- Mutation
- Polymorphism, Genetic
- Prevalence
- Prognosis
- Risk Factors
- Journal Article
- Research Support, Non-U.S. Gov't
Status
Published
Forskningsgrupp
- Clinical Chemistry, Malmö
- Internal Medicine - Epidemiology
- Clinical Coagulation, Malmö
ISBN/ISSN/Övrigt
- ISSN: 0340-6245