Biological variation of retinoids in man.

Summary, in English

This investigation was undertaken to assess biological variation, especially the within-subject variations of all- trans retinoic acid, 13- cis retinoic acid and retinol in human serum. Diurnal variation and variation over a week, a month and a year were studied in 11 males (aged 21 - 54 years) and 17 females (aged 22 - 63 years), all subjectively healthy. We found no diurnal variation with the exception of all- trans retinoic acid, which had maximal concentrations at noon irrespective of food intake. Seasonal variations were marginal. Both all- trans and 13- cis retinoic acids had fairly high within-subject (13.1% and 12.6%, respectively) and between-subject coefficients of variation (15.9% and 21.0%, respectively), while the within-subject CV of retinol was less (5.6%, with a between-subject CV of 21.1%). Thus, the indices of individuality were <1 for all retinoids. The critical differences between two consecutive samples were <40% for the retinoic acids and <20% for retinol. Women had higher all- trans retinoic acid concentrations in serum (5.1 nmol/L vs. 4.5 nmol/L), lower 13- cis retinoic acid concentrations (4.5 nmol/L vs. 5.5 nmol/L) and lower retinol concentrations in serum (2.1 µmol/L vs. 2.5 µmol/L) than men. Thus, samples for retinoid determinations should be drawn in the morning and evaluated using separate gender reference intervals.

• Författare: Maria Berggren Söderlund; Andreas Holmér; G Svärd; G Fex; Peter Nilsson-Ehle
• Avdelning/ar: Avdelningen för klinisk kemi och farmakologi; Klinisk kemi, Malmö
• Publiceringsår: 2002
• Språk: Engelska
• Sidor: 511-519
• Publikation/Tidskrift/Serie: Scandinavian Journal of Clinical & Laboratory Investigation
• Volym: 62
• Issue: 7
• Länkar: http://dx.doi.org/10.1080/003655102321004521
• Dokumenttyp: Artikel i tidskrift
• Förlag: Informa Healthcare
• Ämne: Medicinal Chemistry
• Status: Published
• Forskningsgrupp: Clinical Chemistry, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1502-7686