Grb10 is a dual regulator of receptor tyrosine kinase signaling

Summary, in English

The adaptor protein Grb10 is a close homolog of Grb7 and Grb14. These proteins are characterized by an N-terminal proline-rich region, a Ras–GTPase binding domain, a PH domain, an SH2 domain and a BPS domain in between the PH and SH2 domains. Human Grb10 gene encodes three splice variants. These variants show differences in functionality. Grb10 associates with multiple proteins including tyrosine kinases in a tyrosine phosphorylation dependent or independent manner. Association with multiple proteins allows Grb10 to regulate different signaling pathways resulting in different biological consequences.

• Författare: Nuzhat N. Kabir; Julhash U. Kazi
• Avdelning/ar: BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation; Institutionen för translationell medicin
• Publiceringsår: 2014
• Språk: Engelska
• Sidor: 1985-1992
• Publikation/Tidskrift/Serie: Molecular Biology Reports
• Volym: 41
• Issue: 4
• Fulltext: - 459 kB; Download statistics
• Länkar: http://dx.doi.org/10.1007/s11033-014-3046-4
• Dokumenttyp: Artikel i tidskrift
• Förlag: Springer
• Ämne: Medicinal Chemistry
• Nyckelord: InsR IGF-1R FLT3 KIT PDGFR VEGFR RTK Adaptor
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 0301-4851