Human papillomavirus and Papanicolaou tests to screen for cervical cancer.
Författare
Summary, in English
Background Screening for cervical cancer based on testing for human papillomavirus (HPV) increases the sensitivity of detection of high-grade (grade 2 or 3) cervical intraepithelial neoplasia, but whether this gain represents overdiagnosis or protection against future high-grade cervical epithelial neoplasia or cervical cancer is unknown. Methods In a population-based screening program in Sweden, 12,527 women 32 to 38 years of age were randomly assigned at a 1:1 ratio to have an HPV test plus a Papanicolaou (Pap) test (intervention group) or a Pap test alone (control group). Women with a positive HPV test and a normal Pap test result were offered a second HPV test at least 1 year later, and those who were found to be persistently infected with the same high-risk type of HPV were then offered colposcopy with cervical biopsy. A similar number of double-blinded Pap smears and colposcopies with biopsy were performed in randomly selected women in the control group. Comprehensive registry data were used to follow the women for a mean of 4.1 years. The relative rates of grade 2 or 3 cervical intraepithelial neoplasia or cancer detected at enrollment and at subsequent screening examinations were calculated. Results At enrollment, the proportion of women in the intervention group who were found to have lesions of grade 2 or 3 cervical intraepithelial neoplasia or cancer was 51% greater (95% confidence interval [CI], 13 to 102) than the proportion of women in the control group who were found to have such lesions. At subsequent screening examinations, the proportion of women in the intervention group who were found to have grade 2 or 3 lesions or cancer was 42% less (95% CI, 4 to 64) and the proportion with grade 3 lesions or cancer was 47% less (95% CI, 2 to 71) than the proportions of control women who were found to have such lesions. Women with persistent HPV infection remained at high risk for grade 2 or 3 lesions or cancer after referral for colposcopy. Conclusions The addition of an HPV test to the Pap test to screen women in their mid-30s for cervical cancer reduces the incidence of grade 2 or 3 cervical intraepithelial neoplasia or cancer detected by subsequent screening examinations.
Avdelning/ar
Publiceringsår
2007
Språk
Engelska
Sidor
1589-1597
Publikation/Tidskrift/Serie
New England Journal of Medicine
Volym
357
Issue
16
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Massachusetts Medical Society
Ämne
- Microbiology in the medical area
Nyckelord
- Adult
- Cervical Intraepithelial Neoplasia: diagnosis
- Cervical Intraepithelial Neoplasia: pathology
- Cervical Intraepithelial Neoplasia: prevention & control
- DNA
- Colposcopy
- Sensitivity and Specificity
- Polymerase Chain Reaction
- Papillomavirus Infections: diagnosis
- Papillomaviridae: isolation & purification
- Mass Screening
- Papillomaviridae: genetics
- Vaginal Smears
- Viral: analysis
- Double-Blind Method
- Female
- Humans
- Uterine Cervical Neoplasms: diagnosis
- Uterine Cervical Neoplasms: prevention & control
- Uterine Cervical Neoplasms: pathology
Status
Published
Forskningsgrupp
- Clinical Microbiology, Malmö
ISBN/ISSN/Övrigt
- ISSN: 0028-4793