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Pharmacodynamic studies of vancomycin, metronidazole and fusidic acid against Clostridium difficile

In English

Författare

Summary, in English

Background: Pharmacodynamic studies of antibiotics have attracted great interest in recent years. However, studies on the pharmacodynamics of different antibiotics against Clostridium difficile are scarce. Methods: The postantibiotic effects (PAE) and the postantibiotic sub-minimum inhibitory concentration (MIC) effects (PA SME) of vancomycin, metronidazole and fusidic acid were investigated by viable counts against three different strains of C. difficile. The killing rate and extent of the three antibiotics against the same strains were also studied by adding 2, 4, 8, 16 and 32 ! MIC of the three antibiotics, respectively. Results: Metronidazole exerted a very rapid bactericidal effect at concentrations of 8 ! MIC and above against all three strains investigated. Vancomycin gave overall less kill in comparison to metronidazole and was bacteriostatic against two of the three strains. Fusidic acid exerted a concentration-dependent killing against two of the strains. Vancomycin exerted short PAEs and PA SMEs against all three strains. Significantly longer PAEs and PA SMEs were noted for fusidic acid. Metronidazole gave similar short PAEs like vancomycin but longer PA SMEs were noted against two of the investigated strains. Conclusion: Metronidazole exerted the most prominent bactericidal effect greater than fusidic acid and greater than vancomycin. Fusidic acid gave overall the longest PAEs and PA SMEs greater than metronidazole and greater than vancomycin. Copyright (C) 2007 S. Karger AG, Basel.

Avdelning/ar

Publiceringsår

2007

Språk

Engelska

Sidor

267-274

Publikation/Tidskrift/Serie

Chemotherapy

Volym

53

Issue

4

Dokumenttyp

Artikel i tidskrift

Förlag

Karger

Ämne

  • Microbiology in the medical area
  • Infectious Medicine

Nyckelord

  • fusidic acid
  • vancomycin
  • metronidazole
  • Clostridium difficile
  • effect
  • postantibiotic sub-MIC
  • pharmacodynamic effect
  • postantibiotic effect

Status

Published

Forskningsgrupp

  • Infectious Diseases Research Unit
  • Clinical Microbiology, Malmö

ISBN/ISSN/Övrigt

  • ISSN: 0009-3157