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Alpha-ketoglutarate decreases serum levels of C-terminal cross-linking telopeptide of type I collagen (CTX) in postmenopausal women with osteopenia: Six-month study

  • Rafal S. Filip
  • Stefan Pierzynowski
  • Birger Lindegard
  • Jan Wernerman
  • Agnieszka Haratym-Maj
  • Malgorzata Podgurniak
Publiceringsår: 2007
Språk: Engelska
Sidor: 89-97
Publikation/Tidskrift/Serie: International Journal for Vitamin and Nutrition Research
Volym: 77
Nummer: 2
Dokumenttyp: Artikel
Förlag: Verlag Hans Huber


Several studies have shown that alpha-ketoglutaric acid (AKG) increases serum levels of proline and has beneficial effects on skeletal development. We studied the effect of alpha-ketoglutaric (AKG) acid calcium salt (6 g AKG and 1,68 Ca/day) or calcium alone (1.68 Ca/day) on serum C-terminal cross-linked telopeptide of type I collagen (CTX) and osteocalcin (OC), as well as lumbar spine bone mineral density (BMD) in a randomized, parallel group, double-blind, 6-month study conducted on 76 postmenopausal women with osteopenia. The maximum decrease of the mean CTX level in the AKG-Ca group was observed after 24 weeks (37.0%, p = 0.006). The differences in CTX between study groups were statistically significant after 12 weeks and 24 weeks. The OC serum level was not affected by treatments. The BMD of the AKG-Ca group increased 1.6% from baseline; however, the difference between treatment groups was estimated as 0.9% (non-significant). This study suggests the potential usefulness of AKG-Ca in osteopenic postmenopausal women. AKG-Ca induced beneficial changes in serum CTX, which was consistent with preserving the bone mass in the lumbar spine; however, the long-term effect needs to be further investigated.



  • Medicine and Health Sciences
  • osteocalcin
  • collagen
  • alpha-ketoglutarate
  • C-terminal cross-linking telopeptide of type I
  • osteopenia
  • bone mineral density (BDM)


  • ISSN: 0300-9831

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