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A polymorphic variant in the MHC2TA gene is not associated with systemic lupus erythematosus

In English

Författare

Summary, in English

Single-nucleotide polymorphisms (SNPs) in the major histocompatibility complex class II transactivator (MHC2TA) gene encoding the class II transactivator have been associated with multiple sclerosis, rheumatoid arthritis, and myocardial infarction in the Swedish population. We used a case-control approach to investigate the prevalence of a relevant variant in Swedish systemic lupus erythematosus (SLE) cohorts to determine whether SLE shares the same MHC2TA susceptibility allele as the other diseases. No differences were observed between cases and control subjects at either the allele or genotype levels. Furthermore, no significant correlations were found when comparing different clinical and serological SLE phenotypes. This particular polymorphism rs3087456 of the MHC2TA gene does not appear to influence genetic susceptibility to SLE in the Swedish population. We conclude that our data support neither allelic nor genotype association between the MHC2TA SNP and SLE.

Publiceringsår

2007

Språk

Engelska

Sidor

412-414

Publikation/Tidskrift/Serie

Tissue Antigens

Volym

70

Issue

5

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Microbiology in the medical area
  • Immunology in the medical area
  • Rheumatology and Autoimmunity

Nyckelord

  • transactivator
  • class II transactivator
  • major histocompatibility complex class II
  • systemic lupus erythematosus

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0001-2815