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Mode of action of acidocin D20079, a bacteriocin produced by the potential probiotic strain, Lactobacillus acidophilus DSM 20079

In English

Författare

Summary, in English

Lactobacillus acidophilus DSM 20079 is the producer of a novel bacteriocin termed acidocin D20079. In this paper, mode of action using three various concentrations of acidocin D20079 (2,048, 128 and 11.3 AU/ml) was determined against an indicator strain L. delbrueckii subsp. lactis DSM 20076. These concentrations all led to marked decreases in both the number of viable cells and in optical density, indicating that the activity of the acidocin D20079 was bactericidal with concomitant cell lysis. Moreover, the probiotic potential of L. acidophilus DSM 20079 was analyzed for its ability to survive and retain viability at conditions (acid and bile concentrations) mimicking the gastrointestinal (GI) tract, under which it survived exposure to pH 2.0 with a 1.2 log cycle reduction in viability and where 45% of the original population survived in a medium containing 0.3% bile for 3 h.

Avdelning/ar

Publiceringsår

2007

Språk

Engelska

Sidor

373-379

Publikation/Tidskrift/Serie

Journal of Industrial Microbiology & Biotechnology

Volym

34

Issue

5

Dokumenttyp

Artikel i tidskrift

Förlag

Springer

Ämne

  • Industrial Biotechnology

Nyckelord

  • antimicrobial protein
  • bacteriocin
  • acidocin D20079
  • Lactobacillu
  • inhibitory activity
  • probiotic

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1367-5435