α-l-FucosyItransferases in Human Serum from Donors of Different ABO, Secretor and Lewis Blood-Group Phenotypes
Författare
Summary, in English
The presence of α-l-fucosyltransferases in human serum of different ABO, secretor and Lewis blood-group phenotypes was investigated with guanosine diphosphate fucose as the sugar donor and low-molecular-weight oligosaccharides, or a macromolecular glycoprotein, as acceptors. In contrast to the α-2-l-fucosyltransferases in human milk, submaxillary glands and stomach mucosa that occur only in ABH secretors, an enzyme that transfers l-fucose to the C-2 position of non-reducing β-galactosyl residues was found in the serum of all normal ABO donors irrespective of their ABH secretor-nonsecretor status. The only sera in which the α-2-l-fucosyltransferase was not demonstrable were three examples of the blood group Bombay Oh phenotype and one example of the Bh phenotype. An a-3-l-fucosyltransferase that conveyed L-fucose to the C-3 position in N-acetyl-d-glucosamine or d-glucose occurred in all the sera examined including those from donors of the Bombay Oh and Bh phenotypes. a-4-l-Fucosyltransferase activity was virtually absent from the sera, irrespective of the Lewis blood group of the donors.
Publiceringsår
1972
Språk
Engelska
Sidor
269-277
Publikation/Tidskrift/Serie
European Journal of Biochemistry
Volym
30
Issue
2
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Hematology
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0014-2956