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Heparan sulphate proteoglycans: the sweet side of development.

In English

Författare

Summary, in English

Pattern formation during development is controlled to a great extent by a small number of conserved signal transduction pathways that are activated by extracellular ligands such as Hedgehog, Wingless or Decapentaplegic. Genetic experiments have identified heparan sulphate proteoglycans (HSPGs) as important regulators of the tissue distribution of these extracellular signalling molecules. Several recent reports provide important new insights into the mechanisms by which HSPGs function during development.

Publiceringsår

2005

Språk

Engelska

Sidor

530-541

Publikation/Tidskrift/Serie

Nature Reviews. Molecular Cell Biology

Volym

6

Issue

7

Dokumenttyp

Artikel i tidskrift

Förlag

Nature Publishing Group

Ämne

  • Basic Medicine

Nyckelord

  • Glycosaminoglycans: biosynthesis
  • Gene Expression Regulation
  • Animals
  • N.I.H.
  • U.S. Gov't
  • P.H.S.
  • Signal Transduction
  • Non-U.S. Gov't
  • Research Support
  • Extramural
  • Heparan Sulfate Proteoglycan: genetics
  • Heparan Sulfate Proteoglycan: physiology
  • Humans
  • Mutation

Status

Published

Forskningsgrupp

  • Invertebrate Developmental Biology, Udo Haecker's group

ISBN/ISSN/Övrigt

  • ISSN: 1471-0072