Gerronemins A-F, cytotoxic biscatechols from a Gerronema species
Författare
Summary, in English
The gerronemins A-F (1-6) were isolated as the cytotoxic components of an extract of a Gerronema species detected in a screening for new cytotoxic metabolites from basidiomycetes. Their structures were elucidated by spectroscopic techniques, and they are composed of a C-12-C-16 alkane or alkene substituted at both ends by 2,3-dihydroxyphenyl groups. The gerronemins blocked the inducible expression of a hCOX-2 and iNOS promoter driven reporter gene with IC50-values of 1-5 mug/ml. In addition, cytotoxic activities were observed which were due the inhibition of cellular macromolecular syntheses.
Avdelning/ar
Publiceringsår
2002
Språk
Engelska
Sidor
643-648
Publikation/Tidskrift/Serie
Phytochemistry
Volym
59
Issue
6
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Organic Chemistry
Nyckelord
- cytotoxic activity
- biscatechols
- Gerronema
- gerronemins A-F
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0031-9422