Sulfonylurea-Mediated Stimulation of Insulin Exocytosis via an ATP-Sensitive K(+) Channel--Independent Action.
Författare
Summary, in English
Several reports indicate that hypoglycemic sulfonylureas augment Ca(2+)-dependent insulin secretion via mechanisms other than inhibition of the ATP-sensitive K(+) channel. The effect involves a 65-kd protein in the granule membrane and culminates in intragranular acidification. Lowering of granule pH is necessary for the insulin granule to gain release competence. Proton pumping into the granule is driven by a v-type H(+)-ATPase, but requires simultaneous Cl(-) uptake into the granule via metabolically regulated ClC-3 Cl(-) channels to maintain electroneutrality. Here we discuss the possibility that modulation of granule ClC-3 channels represents the mechanism whereby sulfonylureas directly potentiate the beta-cell exocytotic machinery.
Avdelning/ar
- Diabetes - öpatofysiologi
- Islet cell physiology
Publiceringsår
2002
Språk
Engelska
Sidor
33-36
Publikation/Tidskrift/Serie
Diabetes
Volym
51
Issue
Suppl 1
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
American Diabetes Association Inc.
Ämne
- Endocrinology and Diabetes
Status
Published
Forskningsgrupp
- Diabetes - Islet Patophysiology
- Islet cell physiology
ISBN/ISSN/Övrigt
- ISSN: 1939-327X