Sarcoidosis and Autoimmunity: Evidence of Differential Associations with HLA Class II Markers
Författare
Summary, in English
A high frequency of endocrine autoimmunity
and gastrointestinal immune
reactivity has been reported in sarcoidosis.
The aim of the present study was
to determine the immunogenetic background of
sarcoidosis focusing on the associated autoimmune
manifestations.
Materials and Methods: A total of 66 (38 males,
28 females) and /65 (37 males, 28 females) Caucasian
patients with documented sarcoidosis diagnosed
at the Department of Pulmonary Medicine,
Malmö University Hospital were genomically
typed for DRB1/DQB1.
Results: The frequencies of HLA-DRB1*02
(p=0.004), DRB1*14 (p=0.022), DQB1*0602
(p=0.027), DQB1*0503 (p=0.022), were significantly
increased in the whole group of patients
with sarcoidosis as well as in sarcoidosis associated
with autoimmune manifestations compared
to healthy controls.
Conclusions: Significant associations of HLADRB1*
02 and *14 and DQB1*0602 and *0503 with
sarcoidosis were found, particularly apparent in
the subgroup with associated autoimmune manifestations.
Different immunogenetic profiles
may thus exist in sarcoidosis indicative and/or
causative of distinct clinical subgroups. HLA
class II presentation of a putative sarcoidosisspecific
antigen might be of vital importance in
sarcoidosis, deciding the direction of the sarcoid
disease and eventual associations with it.
Whether the above mentioned HLA class II haplotypes
and/or their linked genes, alone or in
unison with HLA class I, are organ- or diseasespecific
remains to be determined.
and gastrointestinal immune
reactivity has been reported in sarcoidosis.
The aim of the present study was
to determine the immunogenetic background of
sarcoidosis focusing on the associated autoimmune
manifestations.
Materials and Methods: A total of 66 (38 males,
28 females) and /65 (37 males, 28 females) Caucasian
patients with documented sarcoidosis diagnosed
at the Department of Pulmonary Medicine,
Malmö University Hospital were genomically
typed for DRB1/DQB1.
Results: The frequencies of HLA-DRB1*02
(p=0.004), DRB1*14 (p=0.022), DQB1*0602
(p=0.027), DQB1*0503 (p=0.022), were significantly
increased in the whole group of patients
with sarcoidosis as well as in sarcoidosis associated
with autoimmune manifestations compared
to healthy controls.
Conclusions: Significant associations of HLADRB1*
02 and *14 and DQB1*0602 and *0503 with
sarcoidosis were found, particularly apparent in
the subgroup with associated autoimmune manifestations.
Different immunogenetic profiles
may thus exist in sarcoidosis indicative and/or
causative of distinct clinical subgroups. HLA
class II presentation of a putative sarcoidosisspecific
antigen might be of vital importance in
sarcoidosis, deciding the direction of the sarcoid
disease and eventual associations with it.
Whether the above mentioned HLA class II haplotypes
and/or their linked genes, alone or in
unison with HLA class I, are organ- or diseasespecific
remains to be determined.
Avdelning/ar
Publiceringsår
2006
Språk
Engelska
Sidor
13-18
Publikation/Tidskrift/Serie
International Journal of Endocrinology and Metabolism
Volym
4
Issue
1
Dokumenttyp
Artikel i tidskrift
Förlag
Iran Endocrine Society, Shaheed Beheshti University of Medical Sciences
Ämne
- Endocrinology and Diabetes
Nyckelord
- Sarcoidosis
- Thyroid
- Polyglandular Autoimmune Syndromes
- HLA
- Autoimmunity
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1726-913X