Harmful somatic amino acid substitutions affect key pathways in cancers.

Summary, in English

Cancer is characterized by the accumulation of large numbers of genetic variations and alterations of multiple biological phenomena. Cancer genomics has largely focused on the identification of such genetic alterations and the genes containing them, known as 'cancer genes'. However, the non-functional somatic variations out-number functional variations and remain as a major challenge. Recurrent somatic variations are thought to be cancer drivers but they are present in only a small fraction of patients.

• Författare: Abhishek Niroula; Mauno Vihinen
• Avdelning/ar: Proteinbioinformatik; BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
• Publiceringsår: 2015
• Språk: Engelska
• Publikation/Tidskrift/Serie: BMC Medical Genomics
• Volym: 8
• Issue: 1
• Fulltext: - 2 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/26282678?dopt=Abstract; http://dx.doi.org/10.1186/s12920-015-0125-x
• Dokumenttyp: Artikel i tidskrift
• Förlag: BioMed Central (BMC)
• Ämne: Cell and Molecular Biology
• Status: Published
• Forskningsgrupp: Protein Bioinformatics
• ISBN/ISSN/Övrigt: ISSN: 1755-8794