A subset of patients with systemic lupus erythematosus fails to degrade DNA from multiple clinically relevant sources.

Summary, in English

Patients with systemic lupus erythematosus (SLE) have a decreased ability to clear cell remnants and multiple deficiencies in the ability to degrade cellular chromatin have been linked to the disease. Since the discovery of neutrophil extracellular traps (NETs), a renewed interest has been sparked in this field of research with multiple studies reporting a decreased ability of patients with SLE to degrade NETs. In this study we extend these findings by investigating the ability of patients with SLE to degrade chromatin from multiple clinically relevant sources.

• Författare: Jonatan Leffler; Katarzyna Ciacma; Birgitta Gullstrand; Anders Bengtsson; Myriam Martin; Anna Blom
• Avdelning/ar: Proteinkemi, Malmö; Reumatologi och molekylär skelettbiologi; EpiHealth: Epidemiology for Health
• Publiceringsår: 2015
• Språk: Engelska
• Publikation/Tidskrift/Serie: Arthritis Research and Therapy
• Volym: 17
• Fulltext: - 2 MB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/26268365?dopt=Abstract; http://dx.doi.org/10.1186/s13075-015-0726-y
• Dokumenttyp: Artikel i tidskrift
• Förlag: BioMed Central (BMC)
• Ämne: Rheumatology and Autoimmunity
• Status: Published
• Forskningsgrupp: Protein Chemistry, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1478-6362