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Study of ATP-release from acoustically levitated eryhrocytes

Redaktör:
  • Jean-Louis Viovy
  • Patrick Tabeling
  • Stephanie Descroix
  • Laurent Malaquin
Publiceringsår: 2007
Språk: Engelska
Sidor: 1372-1374
Publikation/Tidskrift/Serie: The proceedings of micro total analysis systems 2007
Volym: 2
Dokumenttyp: Konferensbidrag
Förlag: Chemical and Biological Microsystems Society

Sammanfattning

Erythrocytes (red blood cells) are known to produce large amounts of Adenosine Triphosphate (ATP). It has recently become clear that the ATP-release is part of a mechanism controlling the dilation of the body’s blood vessels. The study of the erythrocyte’s behaviour is complicated by the fact that they respond easily to any physical contact. In this paper we propose a new method for studying the dynamics of the ATP-release by combining non-contact acoustic trapping in a microfluidic chip with a chemiluminiscent assay. Sensitivity levels down to 10 pM were achievable and the ATP-release from a cluster of levitated live erythrocytes was recorded.

Disputation

Nyckelord

  • Technology and Engineering
  • Chemiluminiscence
  • Erythrocytes
  • ATP
  • Acoustic trapping

Övriga

Micro Total Analysis Systems 2007
2007-10-07/2007-10-11
Paris
  • Study of ATP-release from acoustically levitated eryhrocytes
Published
Yes
  • ISBN: 978-0-9798064-0-7

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