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Translocation-excision-deletion-amplification mechanism leading to nonsyntenic coamplification of MYC and ATBF1

In English

Författare

  • N Van Roy
  • J Vandesompele
  • B Menten
  • Helén Nilsson
  • E De Smet
  • M Rocchi
  • A De Paepe
  • Sven Påhlman
  • F Speleman

Summary, in English

Despite oncogene amplification being a characteristic of many tumor types, the mechanisms leading to amplicon formation have remained largely unresolved. In this study, we used a combinatorial approach of fluorescence in situ hybridization and single-nucleotide polymorphism chip gene copy number analyses to unravel the mechanism leading to nonsyntenic coamplification of MYC and ATBF1 in SJNB-12 cells. To explain our findings, we propose a complex series of events consisting of multiple double-strand breaks, accompanied (or triggered) by the formation of a reciprocal translocation t(8; 16), as well as excisions and deletions near the translocation breakpoints. This study provides evidence for a translocation-excision-deletion-amplification sequence of events rather than a breakage-fusion-bridge model, which has been more frequently proposed to explain proto-oncogene amplification. Furthermore, it illustrates the power of presently available tools for detailed analysis of the complex rearrangements that accompany amplicon formation.

Publiceringsår

2006

Språk

Engelska

Sidor

107-117

Publikation/Tidskrift/Serie

Genes, Chromosomes and Cancer

Volym

45

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

John Wiley & Sons Inc.

Ämne

  • Cancer and Oncology

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1045-2257