Dietary Fiber-Induced Improvement in Glucose Metabolism Is Associated with Increased Abundance of Prevotella.
Författare
Summary, in English
The gut microbiota plays an important role in human health by interacting with host diet, but there is substantial inter-individual variation in the response to diet. Here we compared the gut microbiota composition of healthy subjects who exhibited improved glucose metabolism following 3-day consumption of barley kernel-based bread (BKB) with those who responded least to this dietary intervention. The Prevotella/Bacteroides ratio was higher in responders than non-responders after BKB. Metagenomic analysis showed that the gut microbiota of responders was enriched in Prevotella copri and had increased potential to ferment complex polysaccharides after BKB. Finally, germ-free mice transplanted with microbiota from responder human donors exhibited improved glucose metabolism and increased abundance of Prevotella and liver glycogen content compared with germ-free mice that received non-responder microbiota. Our findings indicate that Prevotella plays a role in the BKB-induced improvement in glucose metabolism observed in certain individuals, potentially by promoting increased glycogen storage.
Avdelning/ar
- Food for Health Science Centre, Medicon Village
- Food for Health Science Centre
Publiceringsår
2015
Språk
Engelska
Sidor
971-982
Publikation/Tidskrift/Serie
Cell Metabolism
Volym
22
Issue
6
Dokumenttyp
Artikel i tidskrift
Förlag
Cell Press
Ämne
- Nutrition and Dietetics
Status
Published
Projekt
- ANTIDIABETIC FOOD CENTRE
ISBN/ISSN/Övrigt
- ISSN: 1550-4131