Stable Peptide of the Endogenous Opioid Enkephalin Precursor and Breast Cancer Risk.
Författare
Summary, in English
In experimental studies, enkephalins (ENKs) and related opioids have been implicated as negative regulators of breast cancer development by enhancing immune-mediated tumoral defense as well as directly inhibiting cancer cells. We hypothesized that plasma levels of ENKs are predictive of the long-term breast cancer risk. Therefore, our objective was to measure pro-ENK A, a surrogate for mature ENK, and evaluate its predictive value for the development of breast cancer in a large population of middle-aged women and an independent study population.
Avdelning/ar
- Tumörmikromiljön
- EXODIAB: Excellence of Diabetes Research in Sweden
- EpiHealth: Epidemiology for Health
- Kardiovaskulär forskning - hypertoni
- Diabetes - kardiovaskulär sjukdom
- Kirurgi
- Translationell Muskel Forskning
- Internmedicin - epidemiologi
- Kardiovaskulär forskning - epidemiologi
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- Bröstcancer-genetik
- Tumörmikromiljö
Publiceringsår
2015
Språk
Engelska
Sidor
81-2632
Publikation/Tidskrift/Serie
Journal of Clinical Oncology
Volym
33
Issue
24
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
American Society of Clinical Oncology
Ämne
- Cancer and Oncology
Status
Published
Forskningsgrupp
- Tumor microenvironment
- Cardiovascular Research - Hypertension
- Diabetes - Cardiovascular Disease
- Surgery
- Genomics, Diabetes and Endocrinology
- Internal Medicine - Epidemiology
- Cardiovascular Research - Epidemiology
ISBN/ISSN/Övrigt
- ISSN: 1527-7755