Exploring the multifaceted nature of the common lymphoid progenitor compartment.
Författare
Summary, in English
While the common lymphoid progenitor compartment was originally thought to be a rather homogenous cell population, it has become increasingly clear that this compartment is highly heterogeneous both with regard to phenotypic and functional features. The exploration of this cellular complexity has generated novel molecular insights into regulatory events in lymphoid lineage restriction and provided support for the idea that multiple lineage restriction events occur at this developmental stage. Furthermore, the identification of multiple lineage-restricted progenitors with mixed lineage potential challenges a strictly hierarchical model for lymphoid development. Instead we propose a model based on competence windows during which cell fates are established through the action of lineage determining factors.
Avdelning/ar
- Avdelningen för molekylär hematologi
- Molekylär lymfopoes
- BioCARE: Biomarkers in Cancer Medicine improving Health Care, Education and Innovation
- StemTherapy: National Initiative on Stem Cells for Regenerative Therapy
Publiceringsår
2016
Språk
Engelska
Sidor
121-126
Publikation/Tidskrift/Serie
Current Opinion in Immunology
Volym
39
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Developmental Biology
- Cell and Molecular Biology
Status
Published
Forskningsgrupp
- Molecular Lymphopoiesis
ISBN/ISSN/Övrigt
- ISSN: 1879-0372