Identification of a novel protease inhibitor gene that is highly expressed in the prostate.
Författare
Summary, in English
A novel gene was identified 52 kb upstream of the gene encoding the protease inhibitor elafin (PI3) on human chromosome 20q12-13.1. The transcript of the new gene, denoted huWAP2, was characterized by rapid amplification of cDNA ends and DNA sequencing. The size is 774 bp and it gives rise to a polypeptide of 111 amino acid residues that is homologous to elafin and similar WAP-type protease inhibitors. By RT-PCR it was shown that the gene is highly expressed in prostate, skin, lung, and esophagus.
Avdelning/ar
Publiceringsår
2002
Språk
Engelska
Sidor
452-456
Publikation/Tidskrift/Serie
Biochemical and Biophysical Research Communications
Volym
290
Issue
1
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Biological Sciences
Nyckelord
- Male
- Molecular Sequence Data
- Prostate : metabolism
- Protease Inhibitors : chemistry
- Protein Structure Tertiary
- Reverse Transcriptase Polymerase Chain Reaction
- Proteins : biosynthesis : chemistry : genetics
- Sequence Analysis DNA
- Sequence Homology Amino Acid
- Sequence Homology Nucleic Acid
- Tissue Distribution
- Support Non-U.S. Gov't
- Exons
- Human
- DNA Complementary : metabolism
- Chromosomes Human Pair 20
- Base Sequence
- Amino Acid Sequence
Status
Published
Forskningsgrupp
- Clinical Chemistry, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1090-2104