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Familial breast and ovarian cancer : a Swedish population-based register study

In English

Författare

Summary, in English

A cohort of offspring of mothers with breast or ovarian cancer diagnosed in 1958-1993 was established using Swedish population-based registers. The children (n = 158,041) were born between 1941 and 1993, and their cancer incidence was followed between 1961 and 1993. A total of 3,257 tumors in 3,102 children were found. Observed numbers of cases were compared with expected numbers based on national calendar year-, age-, and sex-specific incidences. For daughters of women with breast cancer, the standardized morbidity ratios for being diagnosed with breast cancer and ovarian cancer before age 50 years were 1.99 (95% confidence interval (CI): 1.86, 2.14) and 1.28 (95% CI: 1.05, 1.54), respectively. The corresponding figures for daughters of women with ovarian cancer were 1.79 (95% CI: 1.55, 2.07) and 2.38 (95% CI: 1.77, 3.12). The risks were raised if the mother's cancer was diagnosed at a young age, the mother had multiple breast/ovarian diagnoses, or there was a sister with breast/ovarian cancer. Among all offspring, increased risks were found for thyroid cancer, testicular cancer, and malignant melanoma, while lung cancer risk was decreased if the mother had had breast cancer. The authors developed a variance estimator for the standardized morbidity ratio to cope with overdispersion due to dependency within families.

Publiceringsår

2000-12-15

Språk

Engelska

Sidor

63-1154

Publikation/Tidskrift/Serie

American Journal of Epidemiology

Volym

152

Issue

12

Dokumenttyp

Artikel i tidskrift

Förlag

Oxford University Press

Ämne

  • Cancer and Oncology

Nyckelord

  • Adult
  • Age Distribution
  • Aged
  • Breast Neoplasms
  • Confidence Intervals
  • Female
  • Genetic Predisposition to Disease
  • Humans
  • Incidence
  • Middle Aged
  • Ovarian Neoplasms
  • Population Surveillance
  • Registries
  • Risk Assessment
  • Risk Factors
  • Survival Rate
  • Sweden

Status

Published

Forskningsgrupp

  • Lund Melanoma Study Group

ISBN/ISSN/Övrigt

  • ISSN: 0002-9262