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Vitamin D3 modulates the innate immune response through regulation of the hCAP-18/LL-37 gene expression and cytokine production.

In English

Författare

Summary, in English

The steroid hormone metabolite of vitamin D3, 1α,25-dihydroxyvitamin D3 (1,25D3), promotes osteogenic activity and regulates calcium and phosphate metabolism, which are actions regarded as classical vitamin D-regulated functions. Besides its role in these processes, 1,25D3 also seems implicated in the host defense against microbial/pro-inflammatory attacks. Low serum levels of vitamin D3 (vitamin D deficiency) are associated with osteoporosis and increased risk of fractures but also inflammatory diseases and their disease progression, presumably via mechanisms associated with 1,25D3-evoked modulation of the innate immune system. 1,25D3 has been reported to modulate many inflammatory responses, suggesting that it regulates multiple transcriptional targets within the inflammatory system.

Avdelning/ar

Publiceringsår

2016

Språk

Engelska

Sidor

25-32

Publikation/Tidskrift/Serie

Inflammation Research

Volym

65

Issue

1

Dokumenttyp

Artikel i tidskrift

Förlag

Birkhäuser Verlag

Ämne

  • Immunology in the medical area

Status

Published

Projekt

  • Vitamin D and estrogen receptor signaling

Forskningsgrupp

  • Vascular Physiology

ISBN/ISSN/Övrigt

  • ISSN: 1420-908X