Endogenous IFN-β signaling exerts anti-inflammatory actions in experimentally induced focal cerebral ischemia.

Summary, in English

Interferon (IFN)-β exerts anti-inflammatory effects, coupled to remarkable neurological improvements in multiple sclerosis, a neuroinflammatory condition of the central nervous system. Analogously, it has been hypothesized that IFN-β, by limiting inflammation, decreases neuronal death and promotes functional recovery after stroke. However, the core actions of endogenous IFN-β signaling in stroke are unclear.

• Författare: Ana Inacio; Yawei Liu; Bettina H Clausen; Martina Svensson; Krzysztof Kucharz; Yiyi Yang; Totte Stankovich; Reza Khorooshi; Kate L Lambertsen; Shohreh Issazadeh-Navikas; Tomas Deierborg
• Avdelning/ar: Sektion IV; Neuroinflammation; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publiceringsår: 2015
• Språk: Engelska
• Publikation/Tidskrift/Serie: Journal of Neuroinflammation
• Volym: 12
• Issue: 1
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/26581581?dopt=Abstract; http://dx.doi.org/10.1186/s12974-015-0427-0
• Dokumenttyp: Artikel i tidskrift
• Förlag: BioMed Central (BMC)
• Ämne: Neurosciences
• Aktiv: Published
• Forskningsgrupp: Neuroinflammation
• ISBN/ISSN/Övrigt: ISSN: 1742-2094