Molecular analysis of Philadelphia-positive childhood chronic myeloid leukemia.

Summary, in English

The breakpoints in chromosome 22 were determined in five children with Philadelphia-positive chronic myeloid leukemia. All had rearrangements within the major breakpoint cluster region (M-bcr). Four patients had breakpoints in the 5' region of M-bcr (zones 1-3), whereas one had a rearrangement in the 3' region (zone 4). The patient with the 3' rearrangement was the only one to develop a lymphoid blast crisis; he also had a substantially longer survival (102 months) than the others (11-54 months).

• Författare: Thoas Fioretos; Sverre Heim; Stanislaw Garwicz; J Ludvigsson; Felix Mitelman
• Avdelning/ar: Avdelningen för klinisk genetik; Pediatrik, Lund
• Publiceringsår: 1992
• Språk: Engelska
• Sidor: 723-725
• Publikation/Tidskrift/Serie: Leukemia
• Volym: 6
• Issue: 7
• Dokumenttyp: Artikel i tidskrift
• Förlag: Nature Publishing Group
• Ämne: Cancer and Oncology
• Status: Published
• ISBN/ISSN/Övrigt: ISSN: 1476-5551