The assessment of serum-mediated phagocytosis of necrotic material by polymorphonuclear leukocytes to diagnose and predict the clinical features of systemic lupus erythematosus: an observational longitudinal study

Summary, in English

Serum-mediated phagocytosis of antibody- and complement-opsonized necrotic cell material (NCM) by polymorphonuclear leukocytes can be quantified by using a flow cytometry–based assay. The phagocytosis of necrotic cell material (PNC) assay parallels the well-known lupus erythematosus cell test. In this study, we aimed to investigate the diagnostic accuracy of the assay and the relationship with clinical manifestations and disease activity in systemic lupus erythematosus (SLE).

• Författare: Michele Compagno; Birgitta Gullstrand; Sören Jacobsen; Gro Ö Eilertsen; Jan-Åke Nilsson; Christian Lood; Andreas Jönsen; Lennart Truedsson; Gunnar Sturfelt; Anders Bengtsson
• Avdelning/ar: Reumatologi och molekylär skelettbiologi; Joint and Soft Tissue Unit; Ortopedi - klinisk och molekylär osteoporosforskning; Avdelningen för mikrobiologi, immunologi och glykobiologi - MIG; EpiHealth: Epidemiology for Health
• Publiceringsår: 2016
• Språk: Engelska
• Publikation/Tidskrift/Serie: Arthritis Research and Therapy
• Volym: 18
• Fulltext: - 1 MB; Download statistics
• Länkar: http://dx.doi.org/10.1186/s13075-016-0941-1
• Dokumenttyp: Artikel i tidskrift
• Förlag: BioMed Central (BMC)
• Ämne: Rheumatology and Autoimmunity
• Nyckelord: Systemic lupus erythematosus; Biomarkers; Diagnostic accuracy; Flow cytometry; Disease activity; Lupus nephritis
• Status: Published
• Forskningsgrupp: Joint and Soft Tissue Unit; Orthopedics - Clinical and Molecular Osteoporosis Research
• ISBN/ISSN/Övrigt: ISSN: 1478-6362