Optimizing the friability of a tablet formulation
Författare
Summary, in English
The impact on tablet friability caused by the loss-on-drying of the granulation, the granule-size distribution, the lubricant concentration, the compression force, and the pre-compression was scrutinized in a factorially designed experiment. A reduction of friability was obtained by reducing the deviation of the granulation loss-on-drying from approximately 4.6%; by decreasing the lubricant concentration; or by increasing the compression force.
Avdelning/ar
Publiceringsår
1987
Språk
Engelska
Sidor
1063-1067
Publikation/Tidskrift/Serie
Drug Development and Industrial Pharmacy
Volym
13
Issue
6
Dokumenttyp
Artikel i tidskrift
Förlag
Marcel Dekker
Ämne
- Probability Theory and Statistics
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 0363-9045