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Drug Localizations in Tissue by Mass Spectrometry Imaging

In English

Författare

  • Ákos Végvári

Summary, in English

Advances in development of mass spectrometry (MS) are successfully utilized for spatial localization of pharmaceutical compounds in this tissue sections. Today MS instruments can be used in imaging mode when the datasets are generated from the surface of the tissue over an array of acquisition positions. This review is focused on the technological developments of matrix-assisted laser desorption/ionization mass spectrometry imaging (MALDI-MSI) and related sample preparation procedures. MALDI-MSI provides a sensitive and label-free approach for imaging of drugs and their metabolites. Due to these features MALDI-MSI is expected to become a standard technique in pharmaceutical development providing complementary information to current methods.

Publiceringsår

2015

Språk

Engelska

Sidor

869-876

Publikation/Tidskrift/Serie

Biomarkers in Medicine

Volym

9

Issue

9

Dokumenttyp

Artikel i tidskrift

Förlag

Future Medicine Ltd.

Ämne

  • Analytical Chemistry

Nyckelord

  • Cryo-microtome
  • MALDI matrix
  • MALDI-MSI

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1752-0371