TFEB: Pathogenic role and therapeutic target in Parkinson disease.
Författare
Summary, in English
Parkinson disease (PD) is characterized by the progressive loss of nigral dopamine neurons and the presence of accumulations containing the disease-causing protein SNCA/α-synuclein. Here we review our recent findings describing how SNCA impairs the function of the master regulator of the autophagy-lysosomal pathway (ALP), the transcription factor EB (TFEB), and that genetic or pharmacological stimulation of its activity promotes protection of dopamine neurons. These findings suggest that strategies aimed at enhancing autophagy-mediated degradation of SNCA may hold great promise for disease intervention in PD.
Publiceringsår
2013
Språk
Engelska
Sidor
1244-1246
Publikation/Tidskrift/Serie
Autophagy
Volym
9
Issue
8
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Landes Bioscience
Ämne
- Cell and Molecular Biology
Status
Published
Forskningsgrupp
- Neurobiology
ISBN/ISSN/Övrigt
- ISSN: 1554-8635