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Hematopoietic stem cells: the paradigmatic tissue-specific stem cell

In English

Författare

Summary, in English

The recent prospective isolation of a wide variety of somatically derived stem cells has affirmed the notion that homeostatic maintenance of most tissues and organs is mediated by tissue-specific stem and progenitor cells and fueled enthusiasm for the use of such cells in strategies aimed at repairing or replacing damaged, diseased, or genetically deficient tissues and organs. Hematopoietic stem cells (HSCs) are arguably the most well-characterized tissue-specific stem cell, with decades of basic research and clinical application providing not only a profound understanding of the principles of stem cell biology, but also of its potential pitfalls. It is our belief that emerging stem cell fields can benefit greatly from an understanding of the lessons learned from the study of HSCs. In this review we discuss some general concepts regarding stem cell biology learned from the study of HSCs with a highlight on recent work pertaining to emerging topics of interest for stem cell biology.

Avdelning/ar

  • Immunology

Publiceringsår

2006

Språk

Engelska

Sidor

338-346

Publikation/Tidskrift/Serie

American Journal of Pathology

Volym

169

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

American Society for Investigative Pathology

Ämne

  • Cell and Molecular Biology

Status

Published

Forskningsgrupp

  • Immunology

ISBN/ISSN/Övrigt

  • ISSN: 1525-2191