Cerebral perfusion in the elderly with nocturnal blood pressure fall
Författare
Summary, in English
Cerebrovascular disease may be linked with vascular autoregulation in aging. The aim of this study was to examine relation between nocturnal blood pressure (BP) fall and cerebral blood flow (CBF) changes in elderly men. The prospective 'Men born in 1914' cohort study has been in progress since 1968 and included 809 subjects. After 14 years from the last follow up, 97 subjects reached the age of 82 and underwent CBF measurement and 24 h ambulatory blood pressure monitoring. Diastolic BP at night decreased in 84 subjects with median 12.7% and increased in 13 subjects with median 3.7%. Relative diastolic BP fall at night was negatively associated to CBF in temporal and infero-parietal areas. Higher proportion of subjects with increasing systolic BP during the 14-year period was observed in the subgroup with extreme nocturnal diastolic BP dip, irrespectively of BP values or prevalence of hypertension. Extreme nocturnal diastolic BP fall in a cohort of elderly men is correlated with focal changes in CBF. Further studies could explain if increasing BP in the elderly is a cause or result of pathological autoregulation, and if antihypertensive treatment increases nocturnal BP dip.
Avdelning/ar
- Geriatric Medicine
- Sektion IV
Publiceringsår
2007
Språk
Engelska
Sidor
715-720
Publikation/Tidskrift/Serie
European Journal of Neurology
Volym
14
Issue
7
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Wiley-Blackwell
Ämne
- Health Sciences
- Gerontology, specializing in Medical and Health Sciences
- Neurology
Nyckelord
- cerebral blood
- ambulatory blood pressure monitoring
- blood pressure
- flow
- cohort
- elderly
Status
Published
Forskningsgrupp
- Geriatric Medicine
ISBN/ISSN/Övrigt
- ISSN: 1351-5101