Influence of endocrine disruptors on human male fertility
Författare
Summary, in English
It has been suggested that during the past five decades human sperm counts have declined and the incidence of testicular cancer, hypospadias and cryptorchidism has increased. Furthermore, geographical differences, with respect to these markers of male reproductive function, have been reported. According to a recent hypothesis, all these abnormalities of the male genital system do have a common cause, namely exposure to endocrine disruptors affecting the male in early fetal life. Reduced sperm production as well as congenital abnormalities of male genitalia can be evoked in laboratory animals by exposing them to chemicals with endocrine-disrupting effect, and in humans similar effects have been seen following accidental exposures to very high concentrations of these environmental toxicants. However, the evidence for association between levels of exposure found in the general population and serious adverse effects on male reproduction, including fertility, is still lacking. A recent European Union-supported study, on the effect of persistent organohalogen pollutants on human reproduction, failed to show any correlation between post-natal exposure levels and fertility. Future studies will reveal whether prenatal exposure does more strongly affect male fertility and whether genetic predisposition regulates the susceptibility of an individual to the adverse effects of endocrine disruptors.
Publiceringsår
2007
Språk
Engelska
Sidor
633-642
Publikation/Tidskrift/Serie
Reproductive BioMedicine Online
Volym
15
Issue
6
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Reproductive Healthcare Ltd
Ämne
- Obstetrics, Gynecology and Reproductive Medicine
Nyckelord
- Genitalia
- Hazardous Substances: toxicity
- Male: drug effects
- Fertility: drug effects
- Male: abnormalities
- Infertility
- Male: chemically induced
- Male: epidemiology
Status
Published
Forskningsgrupp
- Reproductive medicine, Malmö
ISBN/ISSN/Övrigt
- ISSN: 1472-6491