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Hematopoietic stem cell quiescence attenuates DNA damage response and permits DNA damage accumulation during aging

In English

Författare

  • Derrick J. Rossi
  • Jun Seita
  • Agnieszka Czechowicz
  • Deepta Bhattacharya
  • David Bryder
  • Irving L. Weissman

Summary, in English

The aging of tissue-specific stem and progenitor cells is believed to be central to the pathophysiological conditions arising in aged individuals. While the mechanisms driving stem cell aging are poorly understood, mounting evidence points to age-dependent DNA damage accrual as an important contributing factor. While it has been postulated that DNA damage may deplete stem cell numbers with age, recent studies indicate that murine hematopoietic stem cell (HSC) reserves are in fact maintained despite the accrual of genomic damage with age. Evidence suggests this to be a result of the quiescent (G(0)) cell cycle status of HSC, which results in an attenuation of checkpoint control and DNA damage responses for repair or apoptosis. When aged stem cells that have acquired damage are called into cycle under conditions of stress or tissue regeneration however, their functional capacity was shown to be severely impaired. These data suggest that age-dependent DNA damage accumulation may underlie the diminished capacity of aged stem cells to mediate a return to homeostasis after acute stress or injury. Moreover, the cytoprotection afforded by stem cell quiescence in stress-free, steady-state conditions suggests a mechanism through which potentially dangerous lesions can accumulate in the stem cell pool with age.

Avdelning/ar

  • Immunology

Publiceringsår

2007

Språk

Engelska

Sidor

2371-2376

Publikation/Tidskrift/Serie

Cell Cycle

Volym

6

Issue

19

Dokumenttyp

Artikel i tidskrift

Förlag

Landes Bioscience

Ämne

  • Cell Biology

Nyckelord

  • hematopoietic
  • genomic instability
  • quiescent
  • aging
  • genomic
  • maintenance

Status

Published

Forskningsgrupp

  • Immunology

ISBN/ISSN/Övrigt

  • ISSN: 1551-4005