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Synthesis of Fused Tertazole- and Imidazole Derivatives via Iodocyclization.

In English

Författare

Summary, in English

The possibility to prepare fused tetrazole- and imidazole derivatives by iodocyclization in moderate to excellent yields is demonstrated. In some examples the cyclizations were not following Baldwin's rules entirely, i.e. exo-selectivity. Nucleophilic substitution of the formed iodides gave different results depending on the hardness of the nucleophile. Thus, elimination of the iodide could be a problem but a substitution reaction with ethyl potassium xanthate and a radical reaction using acrylonitrile were tolerated. In addition, we showed that it is possible to selectively use three iodo substituents individually in one of the fused imidazole derivatives.

Publiceringsår

2003

Språk

Engelska

Sidor

6759-6769

Publikation/Tidskrift/Serie

Tetrahedron

Volym

59

Issue

35

Dokumenttyp

Artikel i tidskrift

Förlag

Elsevier

Ämne

  • Organic Chemistry

Status

Published

Forskningsgrupp

  • Chemical Biology and Therapeutics

ISBN/ISSN/Övrigt

  • ISSN: 0040-4020