Mechanisms for motor timing in the cerebellar cortex
Författare
Summary, in English
In classical eyeblink conditioning a subject learns to blink to a previously neutral stimulus. This conditional response is timed to occur just before an air puff to the eye. The learning is known to depend on the cerebellar cortex where Purkinje cells respond with adaptively timed pauses in their spontaneous firing. The pauses in the inhibitory Purkinje cells cause disinhibition of the cerebellar nuclei, which elicit the overt blinks. The timing of a Purkinje cell response was previously thought to require a temporal code in the input signal but recent work suggests that the Purkinje cells can learn to time their responses through an intrinsic mechanism that is activated by metabotropic glutamate receptors (mGluR7).
Avdelning/ar
Publiceringsår
2016
Språk
Engelska
Sidor
53-59
Publikation/Tidskrift/Serie
Current Opinion in Behavioral Sciences
Volym
8
Länkar
Dokumenttyp
Artikel i tidskrift
Förlag
Elsevier
Ämne
- Behavioral Sciences Biology
- Neurosciences
Status
Published
Projekt
- Thinking in Time: Cognition, Communication and Learning
- Thinking in Time: Cognition, Communication and Learning
Forskningsgrupp
- Associative Learning
ISBN/ISSN/Övrigt
- ISSN: 2352-1554