An investigation into whether deletions in 9p reflect prognosis in adult precursor B-cell acute lymphoblastic leukemia : a multi-center study of 381 patients
Författare
Summary, in English
In acute lymphoblastic leukemia, besides age and white cell count at diagnosis, the cytogenetic abnormalities t(9;22)/BCR-ABL and t(4;11)/MLL-AF4 are important prognostic markers and are often included in the treatment stratification of patients with adult acute lymphoblastic leukemia. Deletions in 9p are seen in about 9% of cases of adult acute lymphoblastic leukemia, but their prognostic impact has been controversial. Cytogenetic data from 381 patients diagnosed with B-precursor acute lymphoblastic leukemia were reviewed. Chromosomal analysis was successful in 240 cases. Of these cases, 18 (8%) had abnormalities in 9p and they were compared with patients with normal karyotypes and patients with t(9;22)/BCR-ABL. Patients with abnormalities of chromosome 9 showed significantly shorter overall survival compared with patients with normal karyotypes. In fact, overall survival was similar to that in the poor prognosis t(9;22)/BCR-ABL-positive group. Our data suggest that chromosomal abnormalities involving 9p may have a significant negative impact on survival in adult B-precursor acute lymphoblastic leukemia.
Avdelning/ar
Publiceringsår
2008-11
Språk
Engelska
Sidor
8-1734
Publikation/Tidskrift/Serie
Haematologica
Volym
93
Issue
11
Dokumenttyp
Artikel i tidskrift
Förlag
Ferrata Storti Foundation
Ämne
- Hematology
Nyckelord
- Adolescent
- Adult
- Aged
- Burkitt Lymphoma
- Chromosome Mapping
- Chromosomes, Human, Pair 1
- Chromosomes, Human, Pair 22
- Chromosomes, Human, Pair 9
- Genetic Markers
- Humans
- Karyotyping
- Leukocyte Count
- Middle Aged
- Prognosis
- Sequence Deletion
- Survival Analysis
- Translocation, Genetic
- World Health Organization
Status
Published
ISBN/ISSN/Övrigt
- ISSN: 1592-8721