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Neuroblastoma as an experimental model for neuronal differentiation and hypoxia-induced tumor cell dedifferentiation.

In English

Författare

Summary, in English

Neuroblastoma is a childhood tumor derived from precursor or immature cells of the sympathetic nervous system. Neuroblastomas show a tremendous clinical heterogeneity, encompassing truly benign as well as extremely aggressive forms. In vivo as well as in vitro data have shown that the degree of sympathetic neuronal tumor cell differentiation influences patient outcome. Unraveling mechanisms governing neuroblastoma cell differentiation is therefore a central issue in the neuroblastoma research field. In this communication, we discuss some of the in vitro models frequently used to study human neuroblastoma cell differentiation. We also review recent data demonstrating that oxygen shortage, hypoxia, shifts neuroblastoma cells toward an immature, stem cell-like phenotype and discuss the potential clinical impact of hypoxia on neuroblastoma behavior.

Publiceringsår

2007

Språk

Engelska

Sidor

248-256

Publikation/Tidskrift/Serie

Seminars in Cancer Biology

Volym

17

Issue

3

Dokumenttyp

Artikel i tidskrift

Förlag

Academic Press

Ämne

  • Cancer and Oncology

Nyckelord

  • neuroblastoma
  • hypoxia
  • sympathetic nervous
  • neuronal differentiation
  • system

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1096-3650