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Prediction of disease-related mutations affecting protein localization.

In English

Författare

Summary, in English

Eukaryotic cells contain numerous compartments, which have different protein constituents. Proteins are typically directed to compartments by short peptide sequences that act as targeting signals. Translocation to the proper compartment allows a protein to form the necessary interactions with its partners and take part in biological networks such as signalling and metabolic pathways. If a protein is not transported to the correct intracellular compartment either the reaction performed or information carried by the protein does not reach the proper site, causing either inactivation of central reactions or misregulation of signalling cascades, or the mislocalized active protein has harmful effects by acting in the wrong place.

Publiceringsår

2009

Språk

Engelska

Publikation/Tidskrift/Serie

BMC Genomics

Volym

10

Dokumenttyp

Artikel i tidskrift

Förlag

BioMed Central (BMC)

Ämne

  • Genetics

Nyckelord

  • Computational Biology: methods
  • Genetic Predisposition to Disease: genetics
  • Intracellular Space: metabolism
  • Proteins: genetics
  • Proteins: metabolism

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 1471-2164