In Vitro Activity of Lipopeptides Pal-Lys-Lys-NH2 and Pal-Lys-Lys Alone and in Combination with Antimicrobial Agents against Multiresistant Gram-positive Cocci.

Summary, in English

The in vitro activities of the lipopeptides pahnitoyl (Pal)-Lys-Lys-NH2 and Pal-Lys-Lys against gram-positive cocci were investigated. Enterococci and streptococci demonstrated higher susceptibilities than staphylococci and Rhodococcus equi. A positive interaction was shown when the lipopeptides were combined with beta-lactams and vancomycin. These results suggest that lipopeptides are promising candidates for antimicrobial therapy for infections caused by gram-positive organisms.

• Författare: Wojciech Kamysz; Carmela Silvestri; Oscar Cirioni; Andrea Giacometti; Alberto Licci; Agnese Della Vittoria; Marcin Okroj; Giorgio Scalise
• Avdelning/ar: Klinisk kemi, Malmö
• Publiceringsår: 2007
• Språk: Engelska
• Sidor: 354-358
• Publikation/Tidskrift/Serie: Antimicrobial Agents and Chemotherapy
• Volym: 51
• Issue: 1
• Länkar: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=17060532&dopt=Abstract; http://dx.doi.org/10.1128/AAC.00344-06
• Dokumenttyp: Artikel i tidskrift
• Förlag: American Society for Microbiology
• Ämne: Medicinal Chemistry
• Status: Published
• Forskningsgrupp: Clinical Chemistry, Malmö
• ISBN/ISSN/Övrigt: ISSN: 1098-6596