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Characterization of Sialic Acid Index of Plasma Apolipoprotein J and Phosphatidylethanol During Alcohol Detoxification-A Pilot Study.

In English

Författare

  • Friedrich M Wurst
  • Natasha Thon
  • Wolfgang Weinmann
  • Scott Tippetts
  • Paul Marques
  • Judith A Hahn
  • Christer Alling
  • Steina Aradottir
  • Susanne Hartmann
  • Raj Lakshman

Summary, in English

Background: Apolipoprotein J (ApoJ) is a component of plasma high-density lipoproteins. Previous studies have shown progressive recovery of ApoJ sialic acid content with increased duration of alcohol abstinence. Therefore, the sialic acid index of plasma apolipoprotein J (SIJ) seems to be a promising alcohol biomarker. Phosphatidylethanol (PEth) is a direct ethanol metabolite and has recently attracted attention as a biomarker of prolonged intake of higher amounts of alcohol. The aim of the pilot study was to explore sensitivity, specificity, and normalization of SIJ and PEth in comparison with traditional and emerging biomarkers. Methods: Five male alcohol-dependent patients (International Classification of Diseases 10, F 10.25) were included (median: 40 years old; Alcohol Use Disorders Identification Test value, 30; alcohol consumption in the previous 7 days, 1,680 g). SIJ, PEth, urinary ethyl glucuronide (UEtG), urinary ethyl sulfate (UEtS), and gamma glutamyl-transpeptidase (GGT) were determined at days 1, 3, 7, 10, 14, 21, and 28. Results: At study entry, SIJ, PEth, UEtG, and UEtS were positive in all subjects, whereas GGT and mean corpuscular volume were positive in 3 of 5 (60%) of the subjects. Individual SIJ levels increased between day 1 and 28 between 13.7 and 44.3%, respectively. For SIJ and PEth, the ANOVA (p < 0.005) showed a significant trend with the average subject's SIJ and PEth changing 1.22 and 1.02, respectively, per week. Conclusions: Our preliminary data suggest that SIJ and PEth might hold potential as markers of heavy ethanol intake.

Publiceringsår

2012

Språk

Engelska

Sidor

251-257

Publikation/Tidskrift/Serie

Alcoholism: Clinical and Experimental Research

Volym

36

Issue

2

Dokumenttyp

Artikel i tidskrift

Förlag

Wiley-Blackwell

Ämne

  • Substance Abuse

Nyckelord

  • Phosphatidylethanol
  • Ethyl Glucuronide
  • Alcohol Consumption
  • Sialic Acid Index of Plasma Apolipoprotein J
  • Biomarkers

Status

Published

ISBN/ISSN/Övrigt

  • ISSN: 0145-6008