Functional Studies of microRNAs in Neural Stem Cells : Problems and Perspectives

Summary, in English

In adult mammals, neural stem cells (NSCs) are found in two niches of the brain; the subventricular zone by the lateral ventricles and the subgranular zone of the dentate gyrus in the hippocampus. Neurogenesis is a complex process that is tightly controlled on a molecular level. Recently, microRNAs (miRNAs) have been implicated to play a central role in the regulation of NCSs. miRNAs are small, endogenously expressed RNAs that regulate gene expression at the post-transcriptional level. However, functional studies of miRNAs are complicated due to current technical limitations. In this review we describe recent findings about miRNAs in NSCs looking closely at miR-124, miR-9, and let-7. In addition, we highlight technical strategies used to investigate miRNA function, accentuating limitations, and potentials.

• Författare: Malin Åkerblom; Rohit Sachdeva; Johan Jakobsson
• Avdelning/ar: Molekylär neurogenetik; StemTherapy: National Initiative on Stem Cells for Regenerative Therapy; MultiPark: Multidisciplinary research focused on Parkinson´s disease
• Publiceringsår: 2012
• Språk: Engelska
• Publikation/Tidskrift/Serie: Frontiers in Neuroscience
• Volym: 6
• Fulltext: - 316 kB; Download statistics
• Länkar: http://www.ncbi.nlm.nih.gov/pubmed/22347160?dopt=Abstract; http://dx.doi.org/10.3389/fnins.2012.00014
• Dokumenttyp: Artikel i tidskrift
• Förlag: Frontiers Media S. A.
• Ämne: Neurosciences
• Status: Published
• Forskningsgrupp: Molecular Neurogenetics
• ISBN/ISSN/Övrigt: ISSN: 1662-4548